Vyoopoint has been designed and built to run on Safari, Firefox, Chrome, Opera 8+ and Internet Explorer 7+. It will probably work fine on some older versions of these browsers as long as they have javascript enabled, but certain layout elements may look a bit funky.
Probably nothing you don't already have. The Vyoopoint main image viewer does require the Flash plugin, but chances are pretty good you already have it. If you don't, it's free and easy to install. We'll let you know if you need it and show you how to get it – no worries there.
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